This implementation brief examines gender-based violence (GBV) interventions for young people aged 10–24 in East and Southern Africa (ESA). GBV significantly impacts the sexual, physical and psychological health and well-being of adolescents and youth and interventions that target boys and girls, men and women for prevention, risk mitigation and response and support services are essential. This brief serves as a resource for programmers aiming to implement strategies and understand potential barriers to scaling-up effective programmes. Evidence-based strategies to prevent, mitigate and respond to GBV among adolescents and young people in ESA, include: a) educational approaches, including comprehensive sexuality education (CSE), skill-building and empowerment; b) partner, parent and family-focused strategies; c) response and support services; d) safer schools and environments; e) addressing norms and values through community engagement and (social) media campaigns; f) economic strengthening and empowerment initiatives; and g) policy improvement, implementation and enforcement. Gender-transformative principles and strategies are cross-cutting and inform diverse prevention, risk mitigation and response approaches.