My Body, My Life, My World puts young people at the centre of UNFPA’s work, recognizing their right to make informed choices about their own bodies, their own lives and the world they live in. In 2022 UNFPA is publishing an Operational Guidance on the strategy for the staff of Country and Regional Offices and UNFPA Headquarters. The nine modules, together with a Young People’s Empowerment Index, provide a practical overview and essential tools and resources for the design, implementation and monitoring of programmes, based on the experiences of UNFPA and its partners around the world. Each module introduces and defines the topic, and explains why it is important to UNFPA’s work and the well-being of adolescents and young people. It discusses effective approaches and describes how to plan and implement programmes. Some of the modules address misconceptions about topics that could lead to misunderstanding or opposition, or describe “do’s and don’ts” for implementation. Links to relevant publications and other resources are provided. This operational guidance includes a supplement, the Young People’s Empowerment Index (YPEI). This is an advocacy tool to help national policymakers and programme managers measure progress on youth empowerment in six domains: sexual and reproductive health, gender and autonomy, educational empowerment, economic empowerment, youth policy and political participation, and safety and security.