This policy paper was conceived at a joint LSHTM-Sentebale roundtable meeting in July 2017; three young people from Lesotho and Botswana presented their personal experiences and challenges of living with HIV to an audience including Prince Harry, leading HIV researchers, and senior staff from organisations such as UNAIDS, PEPFAR and the Global Fund to Fight AIDS, TB and Malaria. This paper profiles some promising approaches to address challenges and barriers identified by adolescents living with HIV (ALHIV). This brief is aimed at organisations working with ALHIV who wish to implement evidence-based programmes. The paper provides a snapshot of some promising interventions in sub-Saharan Africa profiled in the recent literature (2010 onwards).