Comprehensive Sexuality Education (CSE) is increasingly gaining traction within the international community. CSE is regarded as an important means of informing young people about their rights and sexual health, improving public health outcomes and contributing to sustainable development. Considerable variation exists in understandings regarding what makes sexuality education ‘comprehensive’. To gain greater clarity on what CSE is seen to be and entails, and how this form of sexuality education compares with other approaches, a review of existing programmatic and scholarly literatures was conducted. This literature review analyses a range of CSE guidelines and academic sources engaging with the subject of CSE, and sexuality education more broadly. Four sets of core CSE components are identified, yet the analysis shows that the intended breadth of this type of sexuality education leaves considerable space for interpretation, with key concepts often remaining abstract. Furthermore, addressing the core elements of CSE and achieving its ‘emancipatory’ goals can work to exclude particular perspectives and subjectivities. The review draws attention to the politics of knowledge production at play in decisions concerning what is deemed ‘comprehensive’, for whom, when and where. It concludes that the notion of ‘comprehensive’ is a matter of degree, and that reaching consensus on a set of universal standards regarding what can be deemed as ‘comprehensive’ may neither be possible nor desirable. The analysis will be useful for those interested in more careful engagement with CSE and, specifically, in examining features that, in practice, may run counter to the original goals.