Around the world, more than 1 billion women and men and boys and girls are living with some form of disability. Although most people will experience disability at some point in their lives, understanding the meaning of disability and its impact on the ability of each individual to be active participants in social, economic, sociocultural, and political life remains a challenge. Physical, social, and legal barriers continue to limit access to education, health care including sexual and reproductive health (SRH), employment, leisure activities, and family life for millions of persons with disabilities worldwide. These barriers can be most acute for young persons with disabilities. The study seeks to contribute to the strengthening of national laws and policies that foster social inclusion and gender equality for the benefit of young persons with disabilities, especially young women and girls with disabilities; eliminate discrimination against them, particularly with regard to access to and enjoyment of sexual and reproductive health and rights and gender-based violence prevention and response services; and recognise and promote their right to be active members of society with the recognised capacity to make decisions on issues affecting them. The study also seeks to identify areas in which data are missing or insufficient and where additional research would be valuable.