The purpose of this guide is to provide teachers with materials and resources to implement the Health and Family Life Education (HFLE) Curriculum. This guide builds on the foundation of the Regional Curriculum Framework for HLFE, which sets out the HFLE philosophy and standards for teaching and identifies the desired knowledge, skills and behavioral outcomes for students. Unit themes and the content of lessons are responsive to the many health and social challenges in the region, including HIV/AIDS, violence and substance abuse. The Guide thus provides schools and teachers with a concrete tool for HFLE implementation. Through the implementation of HFLE lessons in diverse school settings and communities, the goal is to have a positive impact on student health, which in turn, relates to school attendance and learning. Drawing upon lessons learned and needs expressed by teachers over the past few years, the contents of this manual include the following: 1) Background resources and information for teachers on HFLE, Life Skills Education and Interactive Teaching Methods, including developmental tasks of children and adolescents, behavioural theory supporting life skills education, and information for setting ground rules and a respectful classroom atmosphere; 2) A comprehensive overview of the revised HFLE Curriculum; 3) Sample Lesson Plans for HFLE; 4) A list of resource persons/organizations for HFLE.