This is a training manual designed for teacher educators in Sub-Saharan Africa. The training manual is a response to the challenge of controlling the spread of HIV and AIDS Sub-Saharan Africa. It contains the basic facts and information needed in the acquisition of knowledge and the development of attitudes, values, skills and practices related to the prevention and control of the HIV and AIDS pandemic. The manual is presented in 8 modules which aim to provide teacher educators with an experience of engaging in a participatory teaching HIV and AIDS Prevention Education. Some module topics include, the global, regional and local impact of HIV and AIDS; Halting the rampant advance of the pandemic; HIV and AIDS Prevention Education as part of the curriculum for teacher education and the use of participatory teaching strategies and assessment in HIV and AIDS Prevention Education.