The AIDS Mitigation Initiative to Enhance Care and Support in Bukavu, Lubumbashi and Matadi (AMITIE) Project was a four-year community-led, cross-sectoral project to reduce transmission and mitigate the impact of HIV and AIDS in three of Democratic Republic of the Congo's (DRC) major urban centers through sustainable, community-led and multisectoral support to People Living with HIV (PLHIV) and Orphans and Vulnerable Children (OVC). In this consortium project, Catholic Relief Services (CRS) was joined by World Vision International (WV) the Church of Christ in Congo (ECC), and several local faith-based organizations (FBOs) or community-based organizations (CBOs): AMO-Congo, Fondation Femme Plus (FFP), and the Bukavu diocesan HIV and AIDS committee (CODILUSI). AMITIE worked to improve the quality of life for PLHIV and OVC by increasing capacity of communities and CBOs to provide home-based care (HBC) and OVC services; by increasing resilience of OVC and PLHIV households through needs-based support packages; by strengthening the enabling environments that support well-being of OVC at national, provincial, district and local levels; and by strengthening the health services that support and link with home-based care.