UNFPA Palestine, in collaboration with IPPF, has developed the first Technical Guidance on Comprehensive Life Education (CLE) for adolescents and youth (ages 12–18+) in out-of-school settings. Rooted in the Palestinian cultural and legal context, this guidance provides a framework to equip young people with accurate, age-appropriate information on sexual and reproductive health, gender equality, violence prevention, and essential life skills. CLE aims to: empower youth to make informed decisions; promote health, dignity, and respectful relationships; and prevent early marriage, gender-based violence, and unintended pregnancy. The guidance offers practical tools for NGOs, educators, and community actors to implement CLE programmes across Palestine.