Since the beginning of the COVID-19 epidemic in the DRC, the Social Sciences Analytics Cell (CASS) has conducted integrated analyses of the impact of the pandemic and response on the health, protection, and economic security of communities. This report presents an analysis of the impact of school closures as a COVID-19 response measure in the DRC, and is intended to inform evidence-based programming to mitigate the short- and long-term consequences to health, protection, and education of children and adolescents in the DRC. It demonstrates that the impact of school closures does not end with the reopening of schools; the evidence shared in this report highlight the long-term impacts that will continue to be felt following two extended periods of school closures in the DRC, and calls for an urgent response.