The Regional Comprehensive Sexuality Education Resource Package for Out of School Young People was developed to age and developmentally relevant international standards as a comprehensive set of teaching and learning materials for flexible use in settings outside the formal classrooms of the education sector. Several countries of East and Southern Africa have adapted this regional set of materials for nationally endorsed implementation. It comprises the following: (1) Facilitator's Manual, (2) Participant's Workbook, (3) Sexual and Reproductive Health Programme Guide for working with out-of-school young people, (4) Training of Trainers Facilitation guide, (5) 3 posters, (6) 4 pamphlets, (7) CSE observation and monitoring tool, (8) iCAN package for Young People Living with HIV, (9) Tuneme.org mobisite.