This report describes the project research, problems, objectives, methodology, implementation, outputs and outcomes of the five years implementation research project funded by the International Development Research Center (IDRC). The overall aim of this project was to understand the underlying factors that affect the implementation of comprehensive health education for adolescents in and out of school; then to use the information generated to design and implement relevant school and community-based programs that will include teacher and community-based trainings on sexuality education and discussion sessions with adolescents and youth networks to strengthen access to quality comprehensive health education, information and services among in and out of school adolescents in The Gambia.