In this editorial, we consider two articles and attempt to extract lessons for low- and middle-income countries in Asia, Africa, and beyond. There are three main lessons from these special issue articles. First, as Japan’s experience supports, a human resource development system should be established with ownership of the educational sector. Second, a comprehensive school health approach should be established that includes not only school-based activities, but also activities in other sectors, such as the improvement of sanitation, hygiene, and safe food and water, and cooperation with the informal sector. Finally, and most important, school health activities should be supported by legislation from the central government, as was observed in Japan, with the National School Order, which provides legal support for school physicians and school nurses, and demonstrates the government’s commitment to school health. As we indicated in this editorial, it is essential to review what we have achieved, irrespective of the countries in which these achievements have been made, and to summarize lessons for application in the rest of the world.