Monitoring of implementation of collaborative TB/HIV activities and evaluation of impact is critically important. This requires efficient monitoring and evaluation system so as to establish accountability mechanisms between programmes, the population they serve, and donors. The Guide to monitoring and evaluation for collaborative TB/HIV activities will facilitate this process. The first version of the guide was developed in 2004 placing collaborative TB/HIV activities as integral part of national TB/HIV response. It was revised in 2009 to harmonize the approaches and indicators for monitoring and evaluation across key stakeholders. The current revision builds upon remarkable progress in implementation of collaborative TB/HIV activities and aims to strengthen the implementation further through improved quality of data. The 2015 revision of a Guide to monitoring and evaluation for collaborative TB/HIV activities is developed through close collaboration between the World Health Organization, the United States President’s Emergency Plan for AIDS Relief, the Joint United Nations Programme on HIV and AIDS and the Global Fund to Fight AIDS, Tuberculosis and Malaria and extensive consultations with partners and national programmes. It renews focus on quality of data and its utility for programmatic response. The monitoring indicators are broadly categorized into core indicators for global and national level use and optional indicators. While the core indicators enable monitoring of key TB/HIV interventions as in the past, some are modified to enhance accuracy of data and others to broaden scope. Few indicators are also newly introduced for activities that are not monitored systematically at present, such as mortality, risk of tuberculosis among health care workers, the cascade of intensified case finding, access to rapid diagnostics, early antiretroviral therapy (ART) etc. In addition the optional indicators may help monitor other important TB/HIV activities based on the country-specific context and needs.