The Symposium provided a platform for exchange of experience and for reviewing evidence on promising national approaches by the education sector to reach most-at-risk youth. The objectives were set as follows to: 1. review existing evidence on education sector approaches to HIV prevention that reach out to most-at-risk adolescents and youth in different epidemiological settings, and identify the most efficient approaches; 2. exchange experience on factors influencing successful programme planning and implementation; 3. promote education initiatives to enhance HIV prevention measures among adolescents and youth in national and/or regional contexts; and 4. develop recommendations for outreach strategies that target adolescents and youth in an inclusive, gender-sensitive and gender-transformative manner.