The evidence for increased focus on the link between education and health is strong. Education strongly impacts health outcomes and health is equally fundamental to education. This calls for a more comprehensive approach to school health and more coordinated action across sectors. This revised and updated strategy is a roadmap for UNESCO to promote comprehensive sexuality education (CSE) and safe and inclusive learning environments, and place more emphasis on the role of schools and education systems in promoting health and well-being. This strategy guides UNESCO to promote the physical and mental health and well-being of learners. By reducing health-related barriers to learning, such as malnutrition, early and unintended pregnancy, HIV and sexually transmitted infections (STIs) and violence and discrimination, UNESCO, governments and school systems can unlock the potential of all learners.