Life skills and sexuality education programmes usually only focus on HIV negative young people. And HIV prevention seems to be the main target of many of such programmes. However, HIV positive youth also need our attention and care. Fact is that worldwide 40% of all new HIV infections are among young boys and girls, while every day 2,500 other young people are infected. To address the specific needs of young people living with HIV (YPLHIV), this practical guide has been developed. The guide aims to motivate and support professionals who work with young people in life skills and sexuality education programmes and those who develop policies and design programmes in public and private institutions, for instance in schools. It explains how, with small adjustments, existing educational activities can provide HIV positive youth – without disclosing their status – with skills to cope with their status and lead a fulfilling life.