In the context of the Global Education Coalition, formed by UNESCO to support governments in their educational response to COVID-19, UNESCO has collaborated with partners to develop a COVID-19 Response Toolkit in Education. This toolkit contains 9 chapters. The goal of these chapters is to support countries in their basic educational response to COVID-19 by providing practices and examples, concrete steps for intervention, and tactical action checklists. This particular chapter focuses on the topic of safe reopening. It addresses how education systems can put in place health, safety and resurgence protocols during all stages of the school reopening lifecycle that ensures health and safety of students and staff and plans for possible resurgence.