In an effort to mitigate the spread of HIV in developing nations, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) supports HIV prevention programs that emphasize abstinence and be faithful for youth (ABY) among a broader array of prevention interventions. The focus of this report is on multi-country, multi-year PEPFAR ABY programs implemented by 14 nongovernmental and faith-based organizations that were awarded a total of $100 million in central funding by the U.S. Agency for International Development's Office of HIV/AIDS at the beginning of PEPFAR. This paper uses an evaluation tool that compiles known characteristics of high quality reproductive health and HIV prevention curricula to evaluate the strengths and weaknesses of curricula used by centrally-funded PEPFAR ABY programs. Recommendations are made for strengthening the curricula reviewed.