This guide aims to provide guidance to program teams on how to plan an integrated, participatory process for safe school reopening applicable in all contexts across the humanitarian-development nexus. The guide has been developed in response to the global COVID-19 pandemic which led to many school closures and offers a unique multi-sectoral opportunity for governments and school communities to build back better and strengthen the resilience of their education systems. Divided into two sections, the guide includes two Back-to-School Checklists presenting key actions for thematic areas to ensure sectoral integration throughout the school reopening process and top-line actions for head teachers, school management committee or other school structures to follow. The second section provides detailed technical guidance and resources for specific activities mentioned in the checklists.