UNESCO and Peking University collaborated with national authorities in Botswana, Nigeria, and Uganda to strengthen school health education and adolescent well-being in line with national priorities. The initiative focused on reinforcing delivery platforms for school health and sexuality education, building teacher and school staff capacity, strengthening safeguarding and referral mechanisms, and supporting system-level improvements. The experience of Botswana, Nigeria, and Uganda demonstrates that targeted investments in school health and protective systems can strengthen both learner well-being and system capacity. The evidence presented in this report provides a basis for sustained action and strategic investment to ensure that every adolescent - particularly girls - can learn and thrive in safe and supportive schools.