The pandemic is deeply affecting the environment in which girls and all children grow and develop. While children and young people’s health and mortality currently appears less impacted by Covid-19 than older adults, our experience shows that health crises such as this can disproportionately affect girls and all children in a number of ways. Their education will be interrupted, protective structures disrupted, and their families and communities placed under stress by health and economic burdens. Unless addressed, this will have a devastating impact on their longer-term wellbeing and resilience. This paper is based on a review of existing evidence and learning and Plan International experience as well as what we know to date about the Covid-19 impacts on girls and young women.