In the United States, more than 54 million young people are enrolled in elementary and secondary schools. Because young people attend school about six hours a day approximately 180 days per year, schools are in a unique position to help improve the health status of children and adolescents throughout the United States. The Centers for Disease Control and Prevention (CDC), in collaboration with state and local education and health agencies, developed the School Health Profiles (Profiles) to measure school health policies and practices. Profiles has been conducted biennially since 1996 and includes state, large urban school district, territorial, and tribal (through 2012) surveys of principals and lead health education teachers in middle and high schools. Starting in 2014, tribal governments were no longer eligible to receive funding for Profiles. Profiles helps education and health agencies at these various levels monitor and assess characteristics of and trends in school health education; physical education and physical activity; school health policies related to human immunodeficiency virus (HIV), tobacco-use prevention, and nutrition; school-based health services; family engagement; community involvement; and school health coordination.