Skills-based health education for HIV prevention provides learners with the knowledge and skills they need to avoid HIV infection and maintain reproductive health. This document offers practical guidance for those involved in planning, implementing, or strengthening life skills curricula for young people in sub-Saharan Africa. Section I provides background on the issues of adolescent sexuality and vulnerability and implementation of HIV prevention with young people. Section II offers practical tips for implementing life skills programmes for young people, divided into tips for planners, tips for curriculum designers, tips for teacher trainers and head teachers, and tips for administrators. Section III is a bibliography of the documents reviewed for this publication. An annex is also included, which contains a list of examples of life skills curricula and material and contact information.