This document is a qualitative study on higher education institutions’ in Ethiopia HIV and AIDS and gender interventions that can be cited as good practices for the purpose of learning from and identifying what approaches worked best and the underlying reasons for the success. The document provides an important framework in presenting the existing good practices and drawing lessons in an informative way. It was envisaged that documenting the existing good practices and relevant case stories would contribute to the national and international knowledge-base about what was effective in HIV and AIDS interventions in HEIs. More specifically, the major objective was to draw lessons learned from the interventions and inform concerned parties on systematic ways of improving practices.