The National Aboriginal Youth Strategy on HIV and AIDS in Canada serves as guidance and offers a holistic approach for Aboriginal Peoples across Canada to lower the high rates of HIV and AIDS, specifically among Aboriginal youth. NAYSHAC was developed with guidance and input from dedicated youth sitting on the National Aboriginal Youth Council for HIV and AIDS. The success of NAYSHAC is dependent upon the collaboration with CAAN and its partners and the ongoing meaningful involvement of Aboriginal youth across Canada in the shaping of HIV and AIDS related decisions, policy, programming, education and approaches. The strengths and social determinants of health that Aboriginal youth experience have been outlined within a human rights and harm reduction approach. In implementing NAYSHAC, it is highly recommended in implementing its strategies, objectives and goals. Most importantly, an integrated, collaborative, culturally relevant and youth-sensitive approach is central to the success of NAYSHAC. This strategy is offered by CAAN, with guidance and advice from Aboriginal youth, to improve the health and well-being of those living with and affected by HIV and AIDS in Canada.