In the Asia-Pacific Region, young people bear a large proportion of new HIV infections, and there is a need to consult them about how best to tailor prevention initiatives to meet their needs. In 2010, Youth LEAD, an organization representing young HIV advocates from across the Asia-Pacific region highlighted the need to engage young people more effectively in advocacy and programming initiatives. They identified the need for a leadership course designed specifically to equip young people from key populations at higher risk of HIV exposure (herewith referred to as ‘young key populations’) to gain knowledge and skills in communication, advocacy and leadership. Youth LEAD gained technical and financial support from a number of United Nations (UN) and Non-government agencies to assist them to develop and pilot a leadership short course for young key populations. They commissioned a team from the Youth Research Centre, University of Melbourne, Australia to work with a core team of Youth LEAD members on course development, training and piloting of a five-day leadership course titled ‘NewGen Asia’. A training of trainer (ToT) process was used to equip young leaders to deliver the NewGen Asia course to target groups in their own countries. This report documents the process of consultation, curriculum development, training, piloting and refinement of the NewGen Asia course, in the hope that it will inform others embarking on similar youth-led initiatives.