The aim of this study was to document the ways in which primary teacher training colleges respond to the impact of HIV and AIDS and organize their responses to the epidemic. Specifically, the study attempts to identify the impact of HIV and AIDS on staff and trainees in the selected teacher training colleges; identify the existence of institutional policies, structures, action plans, programs and strategies for addressing HIV and AIDS within the colleges; examine the extent to which these strategies are implemented and the obstacles encountered; document the role of different types of management and institutional leadership in organizing strategies for responding to the challenges of HIV and AIDS; and make recommendations on strategies that would help the colleges mitigate the impact of the epidemic and enhance HIV and AIDS awareness among staff and teacher trainees.