This Framework proposes principles and provides guidelines for the introduction of appropriate curricula for comprehensive sexuality education. The aim of this document is to work towards improving access to information concerning sexual and reproductive health as part of the school programme in the Republic of Macedonia through a consultative process involving relevant institutions and civic sector representatives. This document presents justifications and principles, and provides guidelines for the design of appropriate curricula for comprehensive sexuality education. Consequently, this document is aimed at decision makers and should be utilized in the development and implementation of comprehensive sexuality education in the Republic of Macedonia.