This issue of the African Development Perspectives addresses sexual and reproductive health and rights (SRHR) in Africa, with the backdrop of the International Conference on Population and Development (ICPD) Programme of Action (PoA), signed by 179 governments twenty-five years ago, in 1994, in Cairo, Egypt, and the Nairobi Summit in November 2019, where delegates will converge to reaffirm the commitments to accelerate the promises made at the 1994 Conference. Providing a variety of articles on the state of SRHR in Africa, this issue delves into what the evidence says about the successes in SRHR over the past 25 years and points to the gaps in knowledge. It also explores how, and whether, the progress registered so far in achieving good SRHR outcomes, which are fundamental human rights of all girls, boys, men, and women, can be fast-tracked, and how this progress is linked to the achievement of many SDGs.