The imperative to prepare the largest generation of young people in history for adulthood has driven a search for fresh approaches to educating adolescents about their bodies and sexuality. Recently, there have been calls among health experts and educators for a comprehensive, integrated approach to sexuality education that addresses not only health issues such as HIV and pregnancy, but also helps to achieve broader outcomes such as ensuring gender equality, increasing access to education for girls, and improving the quality of education overall. Considerable international attention has been paid to the Family Life and HIV Education (FLHE) program in Nigeria. While the program does not formally aim to achieve broader development goals, nongovernmental organizations in some states have effectively brought a strong commitment to gender equality into local FLHE programs. This report synthesizes a two-tiered review of the FLHE program. It draws both on a formal case study examining effects of the training on teacher attitudes and practices and on a wider, more informal program analysis. The findings from both resonate with each other and are synthesized in this report.