Recent research highlights the need for the assessment of the impact of HIV and AIDS on education in the Caribbean as integral to its mitigation. The analysis presented in this paper is the first to attempt such an assessment. Although only preliminary evaluations of the effects upon the supply of education are made, it is clear that HIV and AIDS may have a significant impact on the education systems in the region. In addition to the quantifiable impact, the impacts of HIV and AIDS may be disproportionate in small states, which predominate in the region. There is a pressing need for the development of country-level multisectoral strategies, increased by the unusually high disparity between Caribbean states. A more in-depth impact assessment is clearly needed to inform this process.