In a bid to achieve the global target to end AIDS by 2030, the National AIDS Council (NAC) in Zimbabwe and the Ministry of Health and Child Care (MoHCC), coalesced with Adolescents and Young People (AYP) to help join the fight against the pandemic. Since 2000, the union between NAC, MoHCC and AYP has been defined by a strategic partnership that has prioritised the inclusion of young people in the development and implementation of national and local HIV programmes. The NAC and MoHCC have developed a promising practice to support the achievement of global targets to end AIDS through meaningful youth engagement. The meaningful inclusion of AYP, from end-to-end, in the HIV response is a process that involved upgrading the status of AYP, from beneficiaries of programmes to agents of change who actively contribute to the design, implementation and monitoring & evaluation (M&E) efforts of HIV treatment and prevention programmes. Special attention was paid to overcoming barriers faced by AYP in participating in decision making processes. This case study aims to 1) demonstrate the way in which Zimbabwe have meaningfully engaged youth in designing, developing, delivering and monitoring the HIV prevention response for AYP in Zimbabwe and 2) demonstrates how AYP are not just programme beneficiaries, but also essential partners and catalysts for change.