These guidelines present a comprehensive approach to sexuality education, encompassing the key components of a broad definition of sexuality including: sexual development, reproductive health, interpersonal relationships, affection, intimacy, body image and gender roles. The guidelines answer basic questions that educators, policymakers and others need to address when they design or evaluate a comprehensive approach to sexuality education. They provide a framework for developing sexuality education curricula, textbooks and programmes, as well as for evaluating existing programmes. The purpose of this document is to provide a model to promote and facilitate the development of comprehensive sexuality education programmes in Nigeria. The guidelines are organized into six key concepts: human development; relationships; personal skills; sexual behaviour; sexual health; society and culture. Each key concept has associated topics, sub concepts and age-appropriate developmental messages. The guidelines reflect a model approach to comprehensive sexuality education and provide a starting point for curriculum development at the local level, as well as offering guidance to policy-makers and local school boards in evaluating existing or proposed programmes. Classroom teachers may use them to provide a theoretical basis for daily programmes. They can also be used in teacher education or in-service training.