The UN International technical guidance on sexuality education was first published in 2009 as an evidence-informed approach for schools, teachers and health educators. Recognizing the dynamic shifts in the field of sexuality education that have occurred since then, an expanded group of UN co-publishing partners has reviewed and updated the content to respond appropriately to the contemporary needs of young learners, and to provide support for education systems and practitioners seeking to address those needs. The International technical guidance on sexuality education (revised edition) provides sound technical advice on the characteristics of effective comprehensive sexuality education (CSE) programmes; a recommended set of topics and learning objectives that should be covered in comprehensive sexuality education; and, recommendations for planning, delivering and monitoring effective CSE programmes. This revised edition of the Guidance reaffirms the position of sexuality education within a framework of human rights and gender equality, and promotes structured learning about sex and relationships in a manner that is positive, affirming, and centred on the best interests of the young person. It is based on a review of the latest evidence and lessons learned from implementing CSE programmes across the globe. The revised Guidance reflects the contribution of sexuality education to the realization of multiple Sustainable Development Goals, notably Goal 3 on good health and well-being for all, Goal 4 on quality education for all, and Goal 5 to achieve gender equality.