A framework for the implementation of sexuality education (SE), called the Whole School Approach (WSA) for sustainable sexuality education was developed by Rutgers, SchoolNet Uganda, Straight Talk Foundation (Uganda), and the Centre for the Study of Adolescence (Kenya). The WSA aims to move beyond classroom teaching and addresses the whole school environment, including supportive school policies and school facilities. The WSA emphasizes the involvement of all relevant stakeholders including students, school management, government officials, peer educators, teachers and sexual and reproductive health service providers. This research seeks to describe and explore how the Whole School Approach for sexuality education addresses challenges related to the implementation of SE programs. Additionally, the current study is seeking evidence on how to increase the scalability, and sustainability of WSA. Therefore, the research question of this study is: How does the Whole School Approach (WSA) improve the implementation of sexuality education in Ugandan schools?