The Responses to Educational Disruption Survey (REDS) is a joint study launched by IEA and UNESCO, in partnership with the European Commission to investigate how teaching and learning were affected by the COVID-19 pandemic, and how education stakeholders responded to the educational disruption, across and within countries. The REDS international report provides a systemic, multi-perspective, and comparative picture of the impact of COVID-19 on secondary education (eighth grade). The study collected data from countries, schools, teachers, and students spanning four continents, including Africa (Burkina Faso, Ethiopia, Kenya, Rwanda), Asia (India, Uzbekistan), Arab region (United Arab Emirates), Europe (Denmark, Russian Federation, Slovenia), and Latin America (Uruguay). This user guide describes the organization, content, and use of the international database from a practical perspective. It is recommended to be used in conjunction with the REDS International Report (Meinck et al. 2022), which provides a comprehensive account of the conceptual, methodological, and analytical implementation of the study. Using both publications in combination will allow analysts to understand and confidently replicate the procedures used, as well as to correctly undertake new analyses in areas of special interest.