Language influences the way we think, how we perceive reality, and how we behave. With respect to HIV, language can embody stigma and discrimination, which impacts access to testing, acquisition of HIV, and engagement with treatment. Language plays a role in supporting respect and empowerment of individuals, as communities shape how they are referred to and the labels they wish to use. Consideration and use of appropriate language can strengthen the global response to the HIV pandemic by diminishing stigma and discrimination and increasing support and understanding for individuals and communities living with HIV. For these reasons, the Joint United Nations Programme on HIV/AIDS (UNAIDS) has developed guidelines for preferred terminology. The guidelines are for use by staff members, colleagues in the Joint Programme’s Cosponsoring organizations, and other partners working in the global response to HIV. The guidelines are rooted in person-centred language, which centres the individual and de-centres their condition or social status.