This study is part of a research strategy to collect baseline data for a newly expanded project carried out by World Education, a non-governmental organization (NGO) established in Ghana in 2001. In partnership with local institutions, World Education strives to prevent the spread and mitigate the impact of HIV/AIDS in the education sector. In collaboration with 12 civil society organizations (CSOs), activities are carried out in nearly 250 schools in four regions targeting students, teachers and parents through an innovative program, Strengthening HIV/AIDS Partnerships in Education (SHAPE). This effort was undertaken to develop an up-to-date picture of the HIV/AIDS knowledge, attitudes and behavior of teachers working in a sub-set of schools participating in the SHAPE 2 program. Among topics explored were teachers' willingness to participate in HIV/AIDS education programs in schools, their knowledge and capacity to do so, and the magnitude of personal risk taking that may put teachers at risk of contracting HIV/AIDS.