The primary aim of TEACH-RSE was to explore the role of teacher professional learning and development in achieving the first of the National Sexual Health Strategy’s goals of ensuring that all people living in Ireland receive comprehensive and age-appropriate sexual health education. More specifically, TEACH-RSE aims to strengthen the provision of RSE on Initial Teacher Education (ITE) programmes, with the objective of contributing to the enhancement of school-based sexuality education and the optimal sexual health and wellbeing of children and young people across their lifespan. Adopting a multi-perspectival approach, TEACH-RSE explored a range of systemic factors pertaining to the preparation of primary and post-primary teachers to teach RSE, which contribute to enhancing and empowering student teachers in their future teaching of RSE. The overall objective is to propose evidence-informed TEACH-RSE Recommendations for RSE provision in ITE to ensure future teachers are competent and confident to provide high-quality comprehensive, inclusive RSE thus enabling lifelong optimal sexual health and wellbeing for all children and young people in Ireland.