This study is part of a UNESCO review in 12 countries to identify promising approaches undertaken by higher education institutions to prevent the spread of HIV, to manage the impact of HIV/AIDS on the higher education sector and to mitigate the effects of HIV/AIDS on individuals, campuses and communities. These approaches will be analysed to identify lessons learned and to make recommendations to higher education institutions to respond appropriately and effectively to HIV/AIDS. The Democratic Republic of the Congo (DRC) is among the three African countries and 12 countries globally selected for the study. In the DRC, four universities (two public and two private) were reviewed. This study highlights the responses, if any, undertaken by these universities with regard to: Establishment and implementation of institutional HIV/AIDS policies and plans; Demonstrated leadership on HIV/AIDS; Education programmes related to HIV/AIDS (including pre and in-service training for university staff, formal and informal education programmes); Research on HIV/AIDS; Development of partnerships and networks; HIV/AIDS programmes and services (prevention, treatment, care, and support); Community outreach; Monitoring and evaluation the institution's response.