This document presents an updated version of a previous UNESCO strategy on HIV and AIDS for Latin America and the Caribbean that covered the period 2004-2005. It is based primarily on the proceedings from the first meeting of the HIV and AIDS Focal Points in the region held in Buenos Aires, Argentina, 1-4 April 2007. The resulting strategy presented in this document is fully consistent with UNESCO's global strategy published earlier in the year.The revised regional strategy seeks to clearly articulate priority core actions for the UNESCO response, building on past experience and UNESCO's longstanding work in this area, and synchronised with the vision, goals, objectives and principles of UNESCO's global strategy. The revised regional strategy, therefore, gives priority to fulfilling UNESCO's responsibilities under the UNAIDS division of labour, including as the lead organization for HIV prevention with young people in educational institutions and as part of broader efforts to support countries to move towards universal access.