The purpose of these manuals is to support a truly sustainable HIV response in the Middle East and North Africa Region (MENA), centered on positive leadership, prevention, education, advocacy, and mentorship. This training-of-trainers (TOT) curriculum was developed because women and men living with HIV (PLHIV) in MENA want to create a specific workshop that builds their skills as trainers, share information and build the first regional network by and for PLHIV. The first step in meeting these goals is to ensure that PLHIV have the correct information about HIV and the best skills and tools to impart this knowledge to others in their countries. The TOT provides a comprehensive program designed to train participants in the skills necessary to delivery high-quality interactive training sessions by and for PLHIV and their communities. It should be used with the subregional training curricula - which participants will obtain during the TOT - to help participants implement their own practicum training, along with the handouts in this TOT manual. The TOT program is divided into six full-day sessions.