Adolescents and youth require sexual and reproductive health information, education, and services globally to see positive health outcomes. This is also true of Muslim youth in the Middle East and North Africa (MENA) region. The controversial nature of sexuality education in the MENA region is not a result of Islamic doctrine but rather the result of cultural sexual taboos being misinterpreted as grounded in Islam. The Western approach to sexuality education should be tailored and culturally adapted to the MENA region because of the differences in history, religion, and culture. Incorporating sexuality education within religious and cultural frameworks is not an easy task and is best achieved through an ongoing process that is open to change and flexible to adaptation based on evidence-based findings.