The Assessment aims to: i) review the existing curriculum and textbooks for students in public sector secondary and higher secondary classes with a view to identify and enlist available content about HIV & AIDS prevention education; ii) measure the level of awareness among adolescent students about HIV & AIDS in general and their knowledge about modes of transmission and precautionary measures; iii) assess the knowledge of young people about adolescence and reproductive health issues; identify possible challenges Pakistan Youth may have to face in their information seeking on their adolescence and reproductive health and discover factors which hinder the transmission and guidance to youth about these aspects. The study was conducted in 9 cities of Pakistan namely; Peshawar, Mansehra, Chakwal, Lahore, Dera Ghazi Khan, Sukkur, Hyderabad, Sibi and Quetta. The findings reveals that while HIV & AIDS prevalence appears to be low in Pakistan at present, the presence of a number of vulnerabilities and risky behavioral patterns suggest the need for urgent, prioritized, and coordinated action to curtail the emergence of a widespread epidemic. Commercial sex Work, needle sharing, poverty, genders based inequalities and low levels of education all contribute to HIV & AIDS vulnerability in Pakistan especially in youth and adolescents who have risky behaviours.