The purpose of this guidance is to help program managers supporting preschools around the world to identify the most appropriate preschool health and nutrition interventions within their context. The guidance is primarily a reference from which program managers can draw from when designing their program. The guide starts with a background on ECCD and preschool education, health and nutrition problems of preschoolers, a recommended approach to preschool H&N, and the information that should be collected prior to program implementation. The guide is then organized by health topic. Each chapter has a first section called “what you need to know about ….”. This contains technical concepts about the health problem and why it is important. Then there is a text box about “interventions”, which means everything that should be done about the problem for 3-5 year old children. There is a box of specific national policies or regulations which you should be familiar with before implementing. The following sections is called “what can preschools do?” which includes a list of things that children, parents and facilitators should learn, know or do. Depending on the problem, there are other actions related to the link with health services or the preschool infrastructure. The next box has information about resources that are needed at the preschool to implement these interventions. The last section is a list of indicators on how to measure progress, at impact, outcome and output level. Finally, each chapter has some references to online resources.