On 7 December 2013, in Cape Town, South Africa, Ministers of Education and Health from 201 countries in Eastern and Southern Africa (ESA) agreed to work collaboratively towards a vision of young Africans who are global citizens of the future, who are educated, healthy, resilient, socially responsible, informed decision-makers, and have the capacity to contribute to their community, country, and region. They affirmed a commitment to the right to the highest possible level of health, education, non-discrimination, and well-being of current and future generations. The Commitment had two sets of targets to be achieved in 2015 and 2020 respectively. By the end of 2015, significant progress towards the ESA Commitment targets could be observed across a number of ESA countries, thanks to concerted action by governments, civil society, and development partners at national and regional level. This report presents the progress made after two years of implementation (2013-2015), and proves that with targeted interventions, sound strategies, adequate resources, and political will, the ESA Commitment targets are attainable. The data presented was obtained and validated through a multi-sectoral country reporting process as stipulated by the respective coordination mechanisms of the ESA Commitment.